Radiesse is the only FDA-approved injectable filler in the United States specifically approved for hand rejuvenation — a meaningful distinction in a category dominated by off-label filler use. With age, the dorsum (top) of the hands progressively loses fat and connective tissue, leaving veins, tendons, and bones visible beneath thinning skin. Radiesse addresses this directly: as a thick, volumizing dermal and subdermal filler, it restores the lost soft tissue layer and softens the appearance of underlying structures. Because it is a non-surgical office-based procedure with no operating room or anesthesia requirement, Radiesse is the fastest path to younger-looking hands for patients who are not candidates for or interested in fat transfer surgery. At Los Angeles Plastic Surgery, Dr. John Anastasatos performs Radiesse filler injections to the hands as part of comprehensive hand rejuvenation.

Dr. Anastasatos performs Radiesse hand injections with the most directly relevant academic credential possible: he completed a fellowship in Hand and Upper Extremity Surgery and Microsurgery at the University of Alabama at Birmingham — formal subspecialty training in the anatomy of the hand that informs the precise injection technique these treatments require. Dr. Anastasatos was profiled by the Beverly Hills Courier in a feature titled “Anastasatos turns Body Restoration into art form” — a profile reflecting his reputation specifically for refined aesthetic results. With over two decades of facial and hand surgical expertise in Beverly Hills since 2007, he is board certified by the American Board of Plastic Surgery, a Fellow of the American College of Surgeons (FACS), a member of the American Society of Plastic Surgeons (ASPS) and American Society for Aesthetic Plastic Surgery (ASAPS), and named by The Luxe Insider as one of the Top 10 Plastic Surgeons in the World.

How Radiesse Works

Radiesse consists of Calcium Hydroxylapatite (CaOH) — a substance that produces two distinct benefits:

• Immediate volumizing effect — the filler restores soft tissue volume on contact, with results visible right away
• Long-term collagen stimulation — the calcium hydroxylapatite stimulates the body’s own collagen production, extending and refining the result over time

This dual mechanism is what distinguishes Radiesse from purely volumizing fillers — the calcium hydroxylapatite component continues working long after the injection itself.

Radiesse for Other Areas

Radiesse is also FDA-approved for correction of nasolabial folds (laugh lines), and Dr. Anastasatos uses it for cheek augmentation as well — where it produces beautiful and substantially volumizing results. The same thickness and durability that make it well-suited to the hands also make it valuable in the midface.

Injection Technique for the Hands

Radiesse behaves well as a deep dermal and subdermal filler — and its thickness and volumizing properties allow injection at multiple anatomical levels for the hands. Dr. Anastasatos’s specific technique uses a sequenced approach:

• First pass — subcutaneous tissue: initial volume restoration in the subcutaneous layer
• Second pass — deep into the metacarpal spaces: filling the deep anatomical spaces between the metacarpal bones for foundational volume
• Third pass — deep dermis: restoring the deeper skin layer for additional volume support
• Fourth pass — skin of the knuckles: improving the wrinkles at the knuckle level for a smoother contour

Comfort and Recovery

Radiesse filler injections to the hand have the advantage and simplicity of an office-based procedure — no operating room, no anesthesia. (By contrast, fat transfer to the hands requires an operating room.) For patient comfort:

• Lidocaine in the syringe — Radiesse syringes contain lidocaine, providing local anesthesia and improving comfort
• Custom topical anesthetic cream — Dr. Anastasatos applies a potent topical anesthetic cream that he formulates with the help of a compounding pharmacy
• Local nerve block option — in some cases, a local anesthetic block is used to numb the entire hand, making the procedure painless

Recovery is fast: any mild edema settles within 48-72 hours, and icing immediately after the procedure helps further. There is no downtime — patients return to normal activities the same day with younger-looking hands.

Schedule a Radiesse Hand Consultation in Beverly Hills

For non-surgical hand rejuvenation with the only FDA-approved hand filler, Dr. Anastasatos welcomes patients to the Beverly Hills office at 436 North Bedford Drive, Suite 202, Beverly Hills, CA 90210, for a private consultation. Contact Los Angeles Plastic Surgery to schedule your appointment with Dr. Anastasatos.